N-Boc-cis-4-Hydroxy-D-proline |
| Catalog No.GC63812 |
La N-Boc-cis-4-hydroxy-D-proline est un lieur ADC non clivable utilisé dans la synthèse de conjugués anticorps-médicament (ADC). La N-Boc-cis-4-Hydroxy-D-proline est également un lieur PROTAC À base de chaÎne alkyle qui peut être utilisé dans le synthé
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 135042-12-5
Sample solution is provided at 25 µL, 10mM.
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N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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