N3-PEG3-CH2CH2COOH |
| Catalog No.GC64177 |
N3-PEG3-CH2CH2COOH un lieur PROTAC À base de PEG peut être utilisé dans la synthèse de BI-3663, BI-4216 et BI-0319.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1056024-94-2
Sample solution is provided at 25 µL, 10mM.
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N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 , BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
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