Nav1.1 activator 1 |
| Catalog No.GC61110 |
L'activateur Nav1.1 1 (composé 4), un activateur Nav1.1 très puissant avec pénétration BBB, augmente la constante de temps de décroissance (tau) des courants Nav1.1 À 0,03 μM avec une sélectivité significative contre Nav1.2, Nav1.5 et Nav1.6.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2332897-85-3
Sample solution is provided at 25 µL, 10mM.
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Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6[1].
Nav1.1 activator 1 (compound 4) is a valuable Nav1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel and has potential for therapeutic treatments of CNS diseases such as Dravet syndrome[1]. Animal Model: Mice[1].
[1]. Miyazaki T, et al. Discovery of novel 4-phenyl-2-(pyrrolidinyl)nicotinamide derivatives as potent Nav1.1 activators. Bioorg Med Chem Lett. 2019 Mar 15;29(6):815-820.
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