NS 1643 |
| Catalog No.GC12424 |
NS 1643 est un agoniste partiel des canaux K(+) du gène lié à l'éther-a-go-go humain (hERG) avec une EC50 de 10,5 μM.
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Cas No.: 448895-37-2
Sample solution is provided at 25 µL, 10mM.
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NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K(+) channels with an EC50 of 10.5 μM. NS1643 has distinct effects on erg2 (Kv11.2) currents by reducing channel inactivation especially at high concentrations[1]. NS1643 increases the repolarization reserve and exhibits an interesting new antiarrhythmic approach[2].
References:
[1]. Sun XJ, et al. The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Front Oncol. 2015 May 26;5:108.
[2]. Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11.
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