OT antagonist 1 |
| Catalog No.GC32425 |
L'antagoniste OT 1 (composé 4) est un puissant antagoniste sélectif de l'ocytocine avec un Ki de 50 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 479080-38-1
Sample solution is provided at 25 µL, 10mM.
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OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
Oxytocin (OT) is a nonapeptide hormone that acts on the OT receptor, a seven-transmembrane (7TM) (Gq-coupled) receptor. The OT receptor has no subtypes but is related to the vasopressin receptors V1A, V1B and V2. OT antagonists have therapeutic potential in a number of areas including pre-term labour: Benign Prostatic Hyperplasia and sexual dysfunction. As a result there is significant interest in the identification of potent, selective, orally bioavailable OT antagonists[1].
[1]. Brown A, et al. Design and optimization of potent, selective antagonists of Oxytocin. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4278-81.
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