OXFBD04 |
| Catalog No.GC39417 |
OXFBD04 est un inhibiteur puissant et sélectif de BRD4 avec une IC50 de 166 nM. OXFBD04 est un puissant ligand du bromodomaine BET avec une affinité supplémentaire modeste pour le bromodomaine CREBBP. OXFBD04 a une activité anticancéreuse.
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Cas No.: 2231747-03-6
Sample solution is provided at 25 µL, 10mM.
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OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166?nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity[1].
[1]. Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957.
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