PD0325901-O-C2-dioxolane |
| Catalog No.GC63554 |
PD0325901-O-C2-dioxolane contient la partie principale de l'inhibiteur de MEK PD0325901. Le PD0325901-O-C2-dioxolane et un ligand de VHL ou CRBN E3 ligase peuvent être utilisés dans la synthèse du dégradeur MEK1/2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2581116-22-3
Sample solution is provided at 25 µL, 10mM.
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PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1].
PD0325901 is a non-ATP competitive MEK inhibitor, potently inhibits ERK signaling and proliferation of tumor cells[1].
[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019;62(23):10897-10911.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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