PD0325901-O-C2-dioxolane |
| Catalog No.GC63554 |
PD0325901-O-C2-디옥솔란은 MEK 억제제 PD0325901의 주요 부분을 가지고 있습니다. PD0325901-O-C2-디옥솔란 및 VHL 또는 CRBN E3 리가제의 리간드는 MEK1/2 분해기의 합성에 사용될 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2581116-22-3
Sample solution is provided at 25 µL, 10mM.
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PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1].
PD0325901 is a non-ATP competitive MEK inhibitor, potently inhibits ERK signaling and proliferation of tumor cells[1].
[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019;62(23):10897-10911.
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