PF 06726304 acetate |
| Catalog No.GC50367 |
Highly potent and SAM-competitive EZH2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2080306-28-9
Sample solution is provided at 25 µL, 10mM.
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Highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.
Kung et al (2016) Design and synthesis of pyridone-containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of enhancer of zeste homolog 2 (EZH2) inhibitors. J.Med.Chem. 59 8306 PMID:27512831
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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