Pitavastatin lactone |
| Catalog No.GC44650 |
La pitavastatine lactone est un métabolite majeur de la pitavastatine chez l'homme.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 141750-63-2
Sample solution is provided at 25 µL, 10mM.
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Pitavastatin lactone is a major phase 2 metabolite of pitavastatin , an inhibitor of HMG-CoA reductase, that is found in plasma of rats and humans following oral administration., Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyl transferases UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be converted back to pitavastatin via hydrolysis.
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