Quinine (Synonyms: NSC 192949) |
| Catalog No.GC41455 |
La quinine est un agent antipaludique alcaloïde dont les valeurs de CMI varient de 10 à 500 nM pour 60 isolats thaïlandais de P.
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Cas No.: 130-95-0
Sample solution is provided at 25 µL, 10mM.
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Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum. It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine . In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg. Formulations containing quinine have been used in the treatment of uncomplicated malaria.
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