rac-CCT 250863 |
| Catalog No.GC50063 |
rac-CCT 250863 (composé rac-21) est un inhibiteur sélectif et réversible de NEK 2 avec une IC50 de 0,073 µM. rac-CCT 250863 montre de bons effets d'induction de l'arrêt du cycle cellulaire et peut également être antiprolifératif dans les cellules (sensible/résistant au pomalidomide). rac-CCT 250863 induit l'apoptose lorsqu'il est associé au pomalidomide.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1364269-06-6
Sample solution is provided at 25 µL, 10mM.
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Potent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
Innocenti et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 55 3228 PMID:22404346
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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