rac-CCT 250863 |
Katalog-Nr.GC50063 |
rac-CCT 250863 (Verbindung rac-21) ist ein selektiver und reversibler NEK 2-Inhibitor mit einem IC50 von 0,073 µM. rac-CCT 250863 zeigt gute Wirkungen bei der Induktion des Zellzyklusarrests und kann auch in Zellen antiproliferativ wirken (Pomalidomid-sensitiv/resistent). rac-CCT 250863 induziert Apoptose, wenn es mit Pomalidomid kombiniert wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1364269-06-6
Sample solution is provided at 25 µL, 10mM.
Potent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
Innocenti et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 55 3228 PMID:22404346
Average Rating: 5
(Based on Reviews and 1 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *