Ranitidine hydrochloride |
| Catalog No.GC12365 |
Le chlorhydrate de ranitidine est un antagoniste des récepteurs H2 de l'histamine puissant, sélectif et actif par voie orale avec une IC50 de 3,3 μM qui inhibe la sécrétion gastrique.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66357-59-3
Sample solution is provided at 25 µL, 10mM.
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Ranitidine hydrochloride is a histamine H2-receptor antagonist that inhibits stomach acid production. Target: Histamine H2-ReceptorRanitidine hydrochloride is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions [1, 2].
References:
[1]. Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9.
[2]. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81.
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