Remogliflozin etabonate (Synonyms: GSK189075) |
| Catalog No.GC44811 |
L'étabonate de rémogliflozine (GSK189075) est un inhibiteur du cotransporteur sodium glucose (SGLT2) actif par voie orale, sélectif et de faible affinité avec des valeurs Ki de 1,95 μM, 2,14 μM, 43,1 μM, 8,57 μM pour hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectivement.
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Cas No.: 442201-24-3
Sample solution is provided at 25 µL, 10mM.
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Remogliflozin etabonate is a prodrug form of the sodium-glucose transporter 2 (SGLT2) inhibitor remogliflozin A . Remogliflozin etabonate inhibits human SGLT2 and SGLT1 (Kis = 1.95 and 43.1 μM, respectively). It inhibits increases in plasma glucose levels in a glucose tolerance test in a rat model of diabetes induced by streptozotocin when administered at doses of 3 and 10 mg/ml. Remogliflozin etabonate (10 and 30 mg/kg twice per day for 6 weeks) also increases fasting plasma insulin levels and reduces fasting plasma glucose and triglyceride levels, as well as urinary glucose excretion, in a db/db mouse model of diabetes with hyperinsulinemia and obesity.
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