Sec61-IN-1 |
Catalog No.GC64840
One-Click Copy Product Info
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Sec61-IN-1 est un inhibiteur efficace de Sec61(Brevet WO2020176863A1, composé A317).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2484865-42-9
Sample solution is provided at 25 µL, 10mM.
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Sec61-IN-1 est un inhibiteur efficace de Sec61(Brevet WO2020176863A1, composé A317).[1].
Sec61-IN-1 présente une EC50 de 2543nM après une traitement de 48 heurres sur des cellules NCI-H929 cells[1].
References:
[1]National Center for Biotechnology Information (2025). PubChem Patent Summary for WO-2020176863-A1, Thiazole derivatives as protein secretion inhibitors. Retrieved March 1, 2025 from https://pubchem.ncbi.nlm.nih.gov/patent/WO-2020176863-A1.
| Expériences cellulaires [1]: | |
Lignées cellulaires | Les cellules NCI-H929 |
Méthode de préparation | Les cellules NCI-H929 ont été resuspendues dans un milieu RPMI 1640 supplémenté avec 10% de sérum de veau foetal, 2mM de glutamine et 1x de Pénicilline/Streptmycine, puis plaquées dans des plaques de culture cellulaire de 384 puits et traitéses avec des dilutions de Sec61-IN-1 dans DMSO/milieu. Les plaques ont été incubées à 37℃ avec de 5% CO2 pendant 48 heures. Après 48 heures, du Celltiter-Glo a été ajouté à chaque puits et le signal de luciférase a été quantifié pour déterminer la viabilité cellulaire. |
Conditions de réaction | 48h |
Domaines d'application | EC50=2543nM |
References: | |
| Cas No. | 2484865-42-9 | SDF | |
| Formula | C23H22N6OS | M.Wt | 430.53 |
| Solubility | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3227 mL | 11.6136 mL | 23.2272 mL |
| 5 mM | 464.5 μL | 2.3227 mL | 4.6454 mL |
| 10 mM | 232.3 μL | 1.1614 mL | 2.3227 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)