SOS1-IN-1 |
| Catalog No.GC30511 |
SOS1-IN-1 est un inhibiteur sélectif et allostérique de SOS1. SOS1-IN-1 inhibe l'activation du site allostérique et partiellement inhibe l'activation du site catalytique. SOS1-IN-1 a un effet anticancéreux.
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Cas No.: 4551-00-2
Sample solution is provided at 25 µL, 10mM.
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SOS1-IN-1 is a SOS1 inhibitor.
The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with SOS1-IN-1 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK[1].
[1]. ARYL SULFONOHYDRAZIDES. WO 2016077793A1.
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