Squalamine lactate (MSI-1256F) (Synonyms: MSI-1256F) |
| Catalog No.GC32161 |
Le lactate de squalamine (MSI-1256F) est un composé aminostérol découvert dans les tissus de l'aiguillat commun, avec une activité antimicrobienne, et utilisé pour le traitement de la dégénérescence maculaire néovasculaire liée À l'Âge.
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Cas No.: 320725-47-1
Sample solution is provided at 25 µL, 10mM.
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Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.
Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].
Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].
[1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246. [2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.
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