TDI-011536 |
Catalog No.GC65889 |
Le TDI-011536 est un puissant inhibiteur de la Lats kinase, interrompt la signalisation Hippo-Yap et initie la prolifération des cellules du muscle cardiaque lésées. TDI-011536 peut être utilisé dans des études de conservation et de régénération d'organes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2687970-96-1
Sample solution is provided at 25 µL, 10mM.
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].
TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of MÜller glia in human retinal organoids[1].
Cell Proliferation Assay[1]
Cell Line: | human retinal organoids |
Concentration: | 3 µM |
Incubation Time: | 24 h, 5 days |
Result: | Supressed Yap phosphorylation and promoted MÜller glia proliferation. |
TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1].
Animal Model: | Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)[1]. |
Dosage: | 200 mg/kg |
Administration: | Intraperitoneal injections; once. |
Result: | Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day. |
Animal Model: | Male 8-week-old mice (cryolesion model)[1]. |
Dosage: | 100 mg/kg |
Administration: | Intraperitoneal injections; once daily for 2 or 3 days. |
Result: | Promoted cardiomyocytes proliferation. |
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *