TDI-011536 |
| カタログ番号GC65889 |
TDI-011536 は、強力な Lats キナーゼ阻害剤であり、Hippo-Yap シグナル伝達を妨害し、損傷した心筋細胞の増殖を開始します。 TDI-011536 は、臓器の保存と再生の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2687970-96-1
Sample solution is provided at 25 µL, 10mM.
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TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].
TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of MÜller glia in human retinal organoids[1].
Cell Proliferation Assay[1]
| Cell Line: | human retinal organoids |
| Concentration: | 3 µM |
| Incubation Time: | 24 h, 5 days |
| Result: | Supressed Yap phosphorylation and promoted MÜller glia proliferation. |
TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1].
| Animal Model: | Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)[1]. |
| Dosage: | 200 mg/kg |
| Administration: | Intraperitoneal injections; once. |
| Result: | Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day. |
| Animal Model: | Male 8-week-old mice (cryolesion model)[1]. |
| Dosage: | 100 mg/kg |
| Administration: | Intraperitoneal injections; once daily for 2 or 3 days. |
| Result: | Promoted cardiomyocytes proliferation. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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