tetranor-PGDM (Synonyms: tetranorPGD Metabolite, tetranor-Prosatglandin D Metabolite) |
| Catalog No.GC45025 |
Tetranor-PGDM est un métabolite urinaire abondant qui reflète la biosynthèse de la prostaglandine D2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70803-91-7
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.
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