Tramiprosate (Synonyms: Homotaurine, NC 531, NC 758, NSC 77071, 3-Sulfopropylamine) |
| Catalog No.GC17910 |
Tramiprosate (homotaurine), un acide aminé naturel actif par voie orale et pénétrant dans le cerveau présent dans diverses espèces d'algues marines rouges. Le tramiprosate se lie À l'Aβ soluble et maintient l'Aβ sous une forme non fibrillaire. Le tramiprosate est également un analogue du GABA et possède des effets neuroprotecteurs, anticonvulsifs et antihypertenseurs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3687-18-1
Sample solution is provided at 25 µL, 10mM.
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Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg.
References:
[1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.
[2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11.
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