Trovirdine (LY300046) |
| Catalog No.GC32124 |
La trovirdine (LY300046) inhibe la RT du VIH-1 avec une IC50 de 7 nM lors de l'utilisation d'une amorce/matrice hétéropolymérique (oligo-ADN/ARN ribosomal) et de dGTP comme substrat.
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Cas No.: 149488-17-5
Sample solution is provided at 25 µL, 10mM.
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Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.IC50 value: 7 nMTarget: HIV-1Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS.
[1]. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127. [2]. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
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