Trovirdine (LY300046) |
| Catalog No.GC32124 |
Trovirdine(LY300046)은 heteropolymeric primer/template(oligo-DNA/ribosomal RNA) 및 dGTP를 기질로 사용할 때 7nM의 IC50으로 HIV-1 RT를 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 149488-17-5
Sample solution is provided at 25 µL, 10mM.
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Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.IC50 value: 7 nMTarget: HIV-1Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS.
[1]. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127. [2]. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
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