U 93631 |
| Catalog No.GC11013 |
U 93631 est un ligand du récepteur GABAA de nouvelle structure chimique avec IC50 de 100 nM, et il a été démontré qu'il induisait une décroissance rapide et dépendante du temps des courants de Cl de cellules entières induits par le GABA dans les récepteurs GABAA recombinants.
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Cas No.: 152273-12-6
Sample solution is provided at 25 µL, 10mM.
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U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. target: GABAA receptorIC 50: GABAA receptor[1]In vitro: In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization,rather than acting as an open channel blocker. [1]
References:
[1]. Dillon,GH et al.U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.Molecular Pharmacology October 1993, 44 (4) 860-865
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