UAMC-3203 |
| Catalog No.GC40193 |
L'UAMC-3203 est un inhibiteur puissant et sélectif de la ferroptose avec une IC50 de 12 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2271358-64-4
Sample solution is provided at 25 µL, 10mM.
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UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells. It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 µmol/kg. It is not toxic to mice following chronic administration of a 20 µmol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 . In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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