Uridine-5'-diphosphoglucuronic Acid (sodium salt) |
| Catalog No.GC45128 |
L'acide trisodique UDP-glucuronique est un précurseur essentiel des glycoconjugués essentiels dans tous les règnes biologiques, allant des glycosaminoglycanes de mammifères et des polysaccharides de la paroi cellulaire végétale aux glycoglycérolipides des capsules bactériennes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 63700-19-6
Sample solution is provided at 25 µL, 10mM.
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Uridine-5'-diphosphoglucuronic Acid (sodium salt) is an agonist for the P2Y14 receptor. Uridine-5'-diphosphoglucuronic Acid (sodium salt) is also a precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and certain microorganisms, and acts as an activated form of glucose in nucleotide sugar metabolism, serving as a substrate for glucose transferase.
Rat liver microsomes were incubated with 1 µM supinoxin.The addition of Uridine-5'-diphosphoglucuronic Acid (sodium salt) in the NADPH-containing incubation mixture did not lead to significant metabolic profile differences from the mixture containing only NADPH, indicating the negligible contribution of Uridine-5'-diphosphoglucuronic Acid (sodium salt)-dependent metabolism in the microsomal clearance of supinoxin[1]. Metabolic reactions containing FDU-PB-22 and human liver microsomes (HLMs) were independent of NADPH but not Uridine-5'-diphosphoglucuronic Acid (sodium salt) [2].
References:
[1]. Liu P, Wu S, et,al. Identification of the metabolites of tofacitinib in liver microsomes by liquid chromatography combined with high resolution mass spectrometry. Biomed Chromatogr. 2021 Jun;35(6):e5081. doi: 10.1002/bmc.5081. Epub 2021 Feb 10. PMID: 33522621.
[2]. Jones S, Yarbrough AL, et,al. Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22). Xenobiotica. 2019 Dec;49(12):1388-1395. doi: 10.1080/00498254.2019.1580403. Epub 2019 Mar 20. PMID: 30739533; PMCID: PMC7133092.
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