Uridine-5'-diphosphoglucuronic Acid (sodium salt)

Uridine-5'-diphosphoglucuronic Acid (sodium salt) is an agonist for the P2Y14 receptor. Uridine-5'-diphosphoglucuronic Acid (sodium salt) is also a precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and certain microorganisms, and acts as an activated form of glucose in nucleotide sugar metabolism, serving as a substrate for glucose transferase.

Rat liver microsomes were incubated with 1 µM supinoxin.The addition of Uridine-5'-diphosphoglucuronic Acid (sodium salt) in the NADPH-containing incubation mixture did not lead to significant metabolic profile differences from the mixture containing only NADPH, indicating the negligible contribution of Uridine-5'-diphosphoglucuronic Acid (sodium salt)-dependent metabolism in the microsomal clearance of supinoxin^[1]. Metabolic reactions containing FDU-PB-22 and human liver microsomes (HLMs) were independent of NADPH but not Uridine-5'-diphosphoglucuronic Acid (sodium salt) ^[2].

References:
[1]. Liu P, Wu S, et,al. Identification of the metabolites of tofacitinib in liver microsomes by liquid chromatography combined with high resolution mass spectrometry. Biomed Chromatogr. 2021 Jun;35(6):e5081. doi: 10.1002/bmc.5081. Epub 2021 Feb 10. PMID: 33522621.
[2]. Jones S, Yarbrough AL, et,al. Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22). Xenobiotica. 2019 Dec;49(12):1388-1395. doi: 10.1080/00498254.2019.1580403. Epub 2019 Mar 20. PMID: 30739533; PMCID: PMC7133092.