Vornorexant (Synonyms: ORN-0829; TS-142) |
| Catalog No.GC64826 |
Le vornorexant (ORN-0829; TS-142) est un puissant antagoniste double OX1R et OX2R avec des valeurs IC50 de 1,05 nM et 1,27 nM, respectivement.
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Cas No.: 1517965-94-4
Sample solution is provided at 25 µL, 10mM.
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Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research[1].
Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep[1].Vornorexant exhibits optimal PK properties with a rapid Tmax and short half-lives in rats and dogs. The T1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog[1].
[1]. Aya Futamura, et al. Discovery of ORN0829, a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. Bioorg Med Chem. 2020 Jul 1;28(13):115489.
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