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VU0071063

Catalog No.GC18629 Copy One-Click Copy Product Info

VU0071063 est un ouvreur Kir6.2/SUR1 puissant et spécifique (EC50 = 7,44 μM) et peut être utilisé pour étudier Kir6.2/SUR1 exprimé dans le pancréas et le cerveau.

Products are for research use only. Not for human use. We do not sell to patients.

VU0071063 Chemical Structure

Cas No.: 333415-38-6

Taille Prix Stock Qté
1mg
49,00 $US
En stock
5mg
154,00 $US
En stock
10mg
283,00 $US
En stock
25mg
647,00 $US
En stock
50mg
297,00 $US
En stock
100mg
446,00 $US
En stock

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Avis des clients

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of VU0071063

VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 (EC50 = 7 uM using whole cell patch clamp electrophysiology). It is selective for SUR1-containing Kir6.1 or Kir6.2 channels over SUR2A, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3/2, and voltage-gated potassium channel 2.1. VU0071063 inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells.

Chemical Properties of VU0071063

Cas No. 333415-38-6 SDF
Chemical Name 7-[[4-(1,1-dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Canonical SMILES CN(C(N1C)=O)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O
Formula C18H22N4O2 M.Wt 326.4
Solubility DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 20 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of VU0071063

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.0637 mL 15.3186 mL 30.6373 mL
5 mM 612.7 μL 3.0637 mL 6.1275 mL
10 mM 306.4 μL 1.5319 mL 3.0637 mL
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In vivo Formulation Calculator (Clear solution) of VU0071063

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Avis

Review for VU0071063

Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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