Xaliproden hydrochloride (Synonyms: SR 57746A) |
| Catalog No.GC50027 |
Le chlorhydrate de Xaliproden (SR57746A) est un agoniste puissant, sélectif et actif par voie orale du récepteur 5-HT1A, montre une forte affinité pour les sites de liaison spécifiques de 5-HT1A dans l'hippocampe du rat (IC50 = 3 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 90494-79-4
Sample solution is provided at 25 µL, 10mM.
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Orally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo..
Fournier et al (1993) Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience 55 629 PMID:8413926 |Duong et al (1999) Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons. Br.J.Pharmacol. 128 1385 PMID:10602316 |Bachy et al (1993) Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonist. Fund.Clin.Pharmacol. 7 487
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