YM-53601 |
| Catalog No.GC45174 |
Le YM-53601, un inhibiteur de la squalène synthase, réduit les taux plasmatiques de cholestérol et de triglycérides in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 182959-33-7
Sample solution is provided at 25 µL, 10mM.
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YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively). It inhibits cholesterol biosynthesis in rats (ED50 = 32 mg/kg). YM-53601 dose-dependently reduces plasma triglyceride and non-HDL cholesterol levels in hamsters fed both normal and high-fat diets. It also reduces viral RNA, core and NS3 protein production, and secreted viral particles in Huh7.5.1-8 cells infected with the hepatitis C virus (HCV) strain JFH-1 without affecting cell viability at concentrations ranging from 0.5 to 1.5 μM. YM-53601 (1-10 μM) confers protection against cytotoxicity induced by the bacterial pore-forming toxin pneumolysin in HBE1 and normal human bronchial epithelial (NHBE) cells.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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