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Chromatin/Epigenetics

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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1791)

  • GC13229 structure
    GC13229NVP-BSK805
    CAS: 1092499-93-8
    Purity: >98%

    A potent, selective JAK2 inhibitor

  • GC13237 structure
    GC13237LMK 235
    CAS: 1418033-25-6
    Purity: >99.50%

    A selective inhibitor of HDAC4 and HDAC5

  • GC13249 structure
    GC13249Rucaparib (free base)
    CAS: 283173-50-2
    Purity: >99.00%

    Rucaparib(유리 염기)(AG014699)는 PARP1에 대해 Ki가 1.4nM인 PARP 단백질(PARP-1, PARP-2 및 PARP-3)의 경구 활성, 강력한 억제제입니다. 루카파립(유리 염기)은 적당한 육탄당-6-인산 탈수소효소(H6PD) 억제제입니다. 루카파립(유리 염기)은 거세저항성 전립선암(CRPC) 연구에 대한 잠재력이 있습니다.

  • GC13332 structure
    GC13332Aurora A Inhibitor I
    CAS: 1158838-45-9
    Purity: >99.00%

    A potent and selective inhibitor of Aurora A kinase

  • GC13383 structure
    GC13383EPZ004777
    CAS: 1338466-77-5
    Purity: >98.00%

    EPZ004777은 강력하고 경구 활성인 히스톤 라이신 메틸전달효소 DOT1L 억제제이다(IC₅₀=0.4nM).

  • GC13398 structure
    GC13398RG 108
    CAS: 48208-26-0
    Purity: >99.50%

    RG 108는 강력한 DNA 메틸전달효소 억제제로 IC50 값이 115nM이다.

  • GC13408 structure
    GC13408CI994 (Tacedinaline)
    CAS: 112522-64-2
    Purity: >98.00%

    An inhibitor of HDAC1, -2, and -3

  • GC13417 structure
    GC13417EX-527 S-enantiomer
    CAS: 848193-68-0
    Purity: >98.50%

    EX-527 S-거울상 이성질체((S)-EX-527)는 IC50이 98nM인 강력하고 선택적인 SIRT1 억제제입니다.

  • GC13419 structure
    GC13419ME0328
    CAS: 1445251-22-8
    Purity: >99.50%

    ME0328은 IC50이 0.89±0.28μM인 강력하고 선택적인 ARTD3/PARP3 억제제입니다.

  • GC13433 structure
    GC13433AZ 960
    CAS: 905586-69-8
    Purity: >98.00%

    A JAK2 inhibitor

  • GC13435 structure
    GC13435KD 5170
    CAS: 940943-37-3
    Purity: >98%

    An inhibitor of class I and II HDACs

  • GC13442 structure
    GC13442Sanguinarine chloride
    CAS: 5578-73-4
    Purity: >99.00%

    Sanguinaria Canadensis의 뿌리에서 추출한 벤조페난트리딘 알칼로이드인 Sanguinarine(Sanguinarin) 클로라이드는 활성산소(ROS) 생성을 활성화하여 세포자멸사를 자극할 수 있습니다. Sanguinarine에 의한 세포 사멸은 JNK 및 NF-κB의 활성화와 관련이 있습니다.

  • GC13474 structure
    GC13474Garcinol
    CAS: 78824-30-3
    Purity: >95.00%

    Garcinol은 비특이성 히스톤 아세틸트랜스퍼라제(HATs) p300과 PCAF의 저해제로 IC 50 값이 각각 7μM과 5μM이다.

  • GC13534 structure
    GC13534Lysine-specific Demethylase Inhibitor (1C)
    CAS: 927019-63-4
    Purity: >98%

    lysine-specific demethylase Inhibitor

  • GC13541 structure
    GC13541G007-LK
    CAS: 1380672-07-0
    Purity: >99.00%

    G007-LK는 TNKS1 (IC₅₀=46 nM)과 TNKS2 (IC₅₀=25 nM)의 강력하고 선택적인 억제제이다.

  • GC13558 structure
    GC13558PIM-1 Inhibitor 2
    CAS: 477845-12-8
    Purity: >98%

    A potent PIM-1 kinase inhibitor

  • GC13591 structure
    GC13591TC-H 106
    CAS: 937039-45-7
    Purity: >98.00%

    A tight-binding inhibitor of class I HDACs

  • GC13634 structure
    GC13634(S)-PFI-2 (hydrochloride)
    CAS: 1627607-88-8
    Purity: >98%

    Negative control of (R)-PFI 2 hydrochloride

  • GC13668 structure
    GC13668Phthalazinone pyrazole
    CAS: 880487-62-7
    Purity: >98%

    프탈라지논 피라졸은 IC50이 0.031μM인 오로라-A 키나제의 강력하고 선택적인 경구 활성 억제제입니다. 프탈라지논 피라졸은 유사분열을 정지시키고 후속적으로 증식하는 세포의 세포자멸사를 통해 종양 성장을 억제할 수 있습니다. 프탈라지논 피라졸은 인간 배아 줄기 세포에서 간세포 유사 세포(HLC)를 분화하는 동안 상피-중간엽 전이(EMT)를 억제합니다.

  • GC13706 structure
    GC13706Droxinostat
    CAS: 99873-43-5
    Purity: >99.50%

    An inhibitor of HDAC3, HDAC6, and HDAC8

  • GC13822 structure
    GC13822(-)-JQ1
    CAS: 1268524-71-5
    Purity: >99.50%

    A selective inhibitor of BET bromodomains

  • GC13826 structure
    GC13826JAK2 Inhibitor V, Z3
    CAS: 195371-52-9
    Purity: >98%

    A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK

  • GC13830 structure
    GC13830Baricitinib phosphate
    CAS: 1187595-84-1
    Purity: >99.50%

    A JAK1 and JAK2 inhibitor

  • GC13837 structure
    GC13837SNS-314 Mesylate
    CAS: 1146618-41-8
    Purity: >99.50%

    A pan-Aurora kinase inhibitor