GLPBio

Chromatin/Epigenetics

Read More about this category
Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1939)

  • GC91148 structure
    GC91148JAK Inhibitor 31
    CAS: 2891469-99-9
    Purity: >98.00%

    JAK2 억제제

  • GC91389 structure
    GC91389J27644
    Purity: >95.00%

    J27644는 히스톤 디아세틸레이스 6 (HDAC6; IC50 = 10 nM)의 억제제입니다.

  • GC91435 structure
    GC91435YCH1899
    Purity: >98.00%

    YCH1899는 poly(ADP-ribose) polymerase 1 (PARP1) 및 PARP2의 억제제입니다. (IC50s = 1). 이것은 PARP3, -4, -5A, -5B, -6, -7, -10 및 -12보다 PARP1과 PARP2에 선택적입니다. (IC50s = 1-14.1 nM).

  • GC91506 structure
    GC91506Bayer 18
    CAS: 1251752-12-1
    Purity: >98.00%

    Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM).

  • GC91565 structure
    GC91565GSK199 analog (hydrochloride)
    CAS: 2048226-46-4
    Purity: >95.00%

    GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199.

  • GC91602 structure
    GC91602PFI-6
    CAS: 2675452-91-0
    Purity: >95.00%

    PFI-6 is a chemical probe for the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 140 and 160 nM, respectively).

  • GC91622 structure
    GC91622KAT8 Inhibitor 19
    CAS: 28532-21-0
    Purity: >98.00%

    KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM).

  • GC91689 structure
    GC91689TG46
    CAS: 936091-15-5
    Purity: >98.00%

    TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM).

  • GN10030 structure
    GN10030Fisetin
    CAS: 528-48-3
    Purity: >98.00%

    Fisetin은 많은 과일과 채소에 존재하는 천연 플라보놀이고 다양한 생물학적 활성을 가지고 있다.

  • GN10040 structure
    GN10040Dehydrocorydaline
    CAS: 30045-16-0
    Purity: >98.00%

    Dehydrocorydaline은 코리달리스 리좀의 4가 암모늄 알칼로이드 중 하나이다.

  • GN10114 structure
    GN10114Oroxin A
    CAS: 57396-78-8
    Purity: >98.00%
  • GN10308 structure
    GN10308Chlorogenic acid
    CAS: 327-97-9
    Purity: >98.00%

    Chlorogenic acid은 강력한 신경 보호제이고 바이러스, 균, 산소화물과 종양에 대한 효능이 있다. Chlorogenic acid은 또한 포도당과 지질 대사를 조절하고 인슐린 민감성을 향상시키는데 관여하고 있다.

  • GN10347 structure
    GN10347Nicotinamide (Vitamin B3)
    CAS: 98-92-0
    Purity: >99.50%

    Nicotinamide (Vitamin B3)은 비타민 B3의 아미드 유도체로 SIRT1 (IC50: 50-180 μM) 및 SIRT2 (IC50: 2 μM)의 활동을 억제할 수 있다. Nicotinamide는 세포 내에서 NAD+, ATP, ROS 수준을 증가시킬 수도 있다.

  • GN10357 structure
    GN10357Parthenolide
    CAS: 20554-84-1
    Purity: >98.00%

    Parthenolide는 Eca109, KYSE-510, SiHa, MCF-7 세포에 대해 각각 약 10.3, 13.3, 8.42, 9.54μM의 IC50 값을 가지는 NF-κB 억제제이다(48시간).

  • GN10413 structure
    GN10413Agrimol B
    CAS: 55576-66-4
    Purity: >99.50%
  • GN10442 structure
    GN10442Curculigoside
    CAS: 85643-19-2
    Purity: >99.50%
  • GN10452 structure
    GN10452Paeoniflorin
    CAS: 23180-57-6
    Purity: >98.00%

    Paeoniflorin은 미나리아재비과 Paeonia 식물의 뿌리에서 추출된 피난 모노테르펜 글리코사이드로 다양한 생물학적 활성을 가지고 있다.

  • GN10473 structure
    GN10473Ginkgolide C
    CAS: 15291-76-6
    Purity: >98.00%
  • GN10518 structure
    GN10518Chitosamine hydrochloride
    CAS: 66-84-2
    Purity: >98.00%
  • GN10584 structure
    GN10584Ginsenoside Rk1
    CAS: 494753-69-4
    Purity: >98.00%
  • GN10627 structure
    GN10627Atractylenolide I
    CAS: 73069-13-3
    Purity: >98.00%
  • GN10629 structure
    GN106295,7-dihydroxychromone
    CAS: 31721-94-5
    Purity: >99.00%

    5,7-dihydroxychromone은 땅콩 껍질에서 유래한 플라보노이드 분해 생성물로 벨벳잎, 옥수수, 땅콩 및 밀의 배아근 신장을 억제한다.

  • GN10669 structure
    GN10669Glucosamine sulfate
    CAS: 29031-19-4
    Purity: >98.00%
  • GP10020 structure
    GP10020Histone-H2A-(107-122)-Ac-OH
    Purity: >98.00%

    Histone-H2A peptide