2'-O,4'-C-Methyleneguanosine (Synonyms: LNA-G) |
| Catalog No.GC66655 |
2′-O,4′-C-metilenguanosina (LNA-G) es un análogo de guanina inverso, donde LNA (ácido nucleico bloqueado) es un análogo de ácido nucleico. La modificación de LNA se puede usar en una variedad de aplicaciones, como la afinidad de unión efectiva a secuencias complementarias y una mayor resistencia a la nucleasa que los nucleótidos naturales, lo que ofrece un gran potencial para aplicaciones en el diagnóstico y la investigación de enfermedades. LNA-G también está disponible a través de la ADN polimerasa KOD, que permite la integración de los nucleótidos de LNA-G en la cadena de ADN.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 207131-16-6
Sample solution is provided at 25 µL, 10mM.
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2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand[1][2].
[1]. Rakesh N. Veedu, et al. Polymerase directed incorporation studies of LNA-G nucleoside 5′-triphosphate and primer extension involving all four LNAnucleotides. New J. Chem., 2010,34, 877-879
[2]. Haase L, et al. Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design. Nucleic Acids Res. 2020 Oct 9;48(18):10555-10566.
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