2'-O,4'-C-Methyleneguanosine (Synonyms: LNA-G) |
| Katalog-Nr.GC66655 |
2′-O,4′-C-Methylenguanosin (LNA-G) ist ein reverses Guanin-Analogon, wobei LNA (Locked Nucleinsäure) ein Nukleinsäure-Analogon ist. Die LNA-Modifikation kann in einer Vielzahl von Anwendungen verwendet werden, wie z. B. effektive Bindungsaffinität zu komplementären Sequenzen und größere Nukleaseresistenz als natürliche Nukleotide, was ein großes Potenzial für Anwendungen in der Krankheitsdiagnose und -forschung bietet. LNA-G ist auch über die KOD-DNA-Polymerase verfügbar, die die Integration von LNA-G-Nukleotiden in den DNA-Strang ermöglicht.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 207131-16-6
Sample solution is provided at 25 µL, 10mM.
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2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand[1][2].
[1]. Rakesh N. Veedu, et al. Polymerase directed incorporation studies of LNA-G nucleoside 5′-triphosphate and primer extension involving all four LNAnucleotides. New J. Chem., 2010,34, 877-879
[2]. Haase L, et al. Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design. Nucleic Acids Res. 2020 Oct 9;48(18):10555-10566.
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