2'-O,4'-C-Methyleneguanosine (Synonyms: LNA-G) |
| Catalog No.GC66655 |
2ò-O,4ò-C-Méthylèneguanosine (LNA-G) est un analogue de guanine inverse, où LNA (acide nucléique verrouillé) est un analogue d'acide nucléique. La modification de LNA peut être utilisée dans une variété d'applications telles qu'une affinité de liaison efficace avec des séquences complémentaires et une plus grande résistance aux nucléases que les nucléotides naturels, offrant un grand potentiel pour des applications dans le diagnostic et la recherche de maladies. LNA-G est également disponible via l'ADN polymérase KOD, qui permet l'intégration des nucléotides LNA-G dans le brin d'ADN.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 207131-16-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand[1][2].
[1]. Rakesh N. Veedu, et al. Polymerase directed incorporation studies of LNA-G nucleoside 5′-triphosphate and primer extension involving all four LNAnucleotides. New J. Chem., 2010,34, 877-879
[2]. Haase L, et al. Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design. Nucleic Acids Res. 2020 Oct 9;48(18):10555-10566.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *