α-NETA |
| Catalog No.GC45213 |
α-NETA es un inhibidor potente y no competitivo de colina acetiltransferasa (ChA; IC50\u003d76 μM) y colinesterasa (ChE; IC50\u003d40 µM). α-NETA inhibe débilmente la acetilcolinesterasa (AChE; IC50\u003d1 mM).
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Cas No.: 31059-54-8
Sample solution is provided at 25 µL, 10mM.
Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer's disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.
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