α-NETA |
| Catalog No.GC45213 |
α-NETA는 강력하고 비경쟁적인 콜린 아세틸트랜스퍼라제(ChA; IC50\u003d76μM) 및 콜린에스테라제(ChE; IC50\u003d40μM) 억제제입니다. α-NETA는 아세틸콜린에스테라아제(AChE; IC50\u003d1mM)를 약하게 억제합니다.
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Cas No.: 31059-54-8
Sample solution is provided at 25 µL, 10mM.
Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer's disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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