AE-3763 |
| Catalog No.GC32016 |
AE-3763 es un inhibidor de la elastasa de neutrÓfilos humanos basado en péptidos con una IC50 de 29 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 291778-77-3
Sample solution is provided at 25 µL, 10mM.
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AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water[1].
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv[1].
[1]. Inoue Y, et al. Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem. 2009 Nov 1;17(21):7477-86.
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