ASP2453 |
| Catalog No.GC64341 |
ASP2453 es un inhibidor de KRAS G12C potente, selectivo y covalente. ASP2453 inhibe la interacciÓn mediada por Son of Sevenless (SOS) entre KRAS G12C y Raf con un valor IC50 de 40 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2241719-73-1
Sample solution is provided at 25 µL, 10mM.
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ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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