ASP2453 |
Katalog-Nr.GC64341 |
ASP2453 ist ein potenter, selektiver und kovalenter KRAS G12C-Inhibitor. ASP2453 hemmt die Son of Sevenless (SOS)-vermittelte Interaktion zwischen KRAS G12C und Raf mit einem IC50-Wert von 40 nM.
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Cas No.: 2241719-73-1
Sample solution is provided at 25 µL, 10mM.
ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.
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