AZ 5704 |
| Catalog No.GC50424 |
Potent and selective ATM kinase inhibitor; orally bioavailable
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1941214-06-7
Sample solution is provided at 25 µL, 10mM.
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Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable.
Degorce et al (2016) Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiectasia mutated (ATM) kinase. J.Med.Chem. 59 6281 PMID:27259031
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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