Carboxylesterase-IN-3 |
| Catalog No.GC65167 |
La carboxilesterasa-IN-3 (compuesto 4y) es un potente inhibidor de la carboxilesterasa Notum con una IC50 inferior o igual a 10 nM. Notum es un regulador negativo de la seÑalizaciÓn de Wnt que actÚa a través de la hidrÓlisis de un éster de palmitoleoylato, que se requiere para la actividad de Wnt. La carboxilesterasa-IN-3 tiene el potencial para la investigaciÓn de la enfermedad del cÁncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2764748-92-5
Sample solution is provided at 25 µL, 10mM.
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Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease[1].
[1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.
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