Hinokiflavone |
| Catalog No.GC38488 |
La hinokiflavona es un nuevo modulador de la actividad de empalme de pre-ARNm in vitro e in celulo. La hinokiflavona bloquea el empalme de sustratos de pre-ARNm al inhibir el ensamblaje del empalmosoma, lo que previene especÍficamente la formaciÓn del complejo B. La hinokiflavona es un inhibidor de la proteasa SUMO que inhibe la actividad de la proteasa 1 especÍfica de sentrina (SENP1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19202-36-9
Sample solution is provided at 25 µL, 10mM.
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Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity[1].
[1]. Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402.
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