Hinokiflavone |
| Catalog No.GC38488 |
L'hinokiflavone est un nouveau modulateur de l'activité d'épissage du pré-ARNm in vitro et in cellulo. L'hinokiflavone bloque l'épissage des substrats de pré-ARNm en inhibant l'assemblage des spliceosomes, empêchant spécifiquement la formation du complexe B. L'hinokiflavone est un inhibiteur de la protéase SUMO, inhibant l'activité de la protéase spécifique de la sentrine 1 (SENP1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19202-36-9
Sample solution is provided at 25 µL, 10mM.
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Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity[1].
[1]. Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402.
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