Hinokiflavone |
| Catalog No.GC38488 |
히노키플라본은 시험관 내 및 셀룰로오스 내에서 pre-mRNA 스플라이싱 활성의 새로운 조절제입니다. 히노키플라본은 spliceosome 조립을 억제하여 특히 B 복합체 형성을 방지함으로써 pre-mRNA 기질의 스플라이싱을 차단합니다. 히노키플라본은 SUMO 프로테아제 억제제로, 센트린 특이적 프로테아제 1(SENP1) 활성을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19202-36-9
Sample solution is provided at 25 µL, 10mM.
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Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity[1].
[1]. Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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