CCMI (Synonyms: AVL-3288; UCI-4083) |
| Catalog No.GC12119 |
CCMI (AVL-3288) es un modulador alostérico positivo de nAChR α7 potente y selectivo, no se une ni activa los nAChR α7 a través del sitio ortostérico y provoca una modulaciÓn positiva significativa de las corrientes inducidas por agonistas en los nAChR α7.
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Cas No.: 917837-54-8
Sample solution is provided at 25 µL, 10mM.
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CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].
CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].
References:
[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.
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