CCMI (Synonyms: AVL-3288; UCI-4083) |
Katalog-Nr.GC12119 |
CCMI (AVL-3288) ist ein potenter und selektiver α7-nAChR-positiver allosterischer Modulator, bindet oder aktiviert α7-nAChRs nicht Über die orthosterische Stelle und verursacht eine signifikante positive Modulation von Agonisten-induzierten StrÖmen bei α7-nAChRs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 917837-54-8
Sample solution is provided at 25 µL, 10mM.
CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].
CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].
References:
[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.
Average Rating: 5
(Based on Reviews and 40 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *