Compound E (Synonyms: γSecretase Inhibitor XXI) |
| Catalog No.GC33118 |
El compuesto E es un γ inhibidor de la secretasa. El compuesto E bloquea β-amiloide(40), β-amiloide(42) y Notch γ-escisiÓn de secretasa con CI50 de 0,24, 0,37, 0,32 nM, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 209986-17-4
Sample solution is provided at 25 µL, 10mM.
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Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1].
[1]. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402. [2]. Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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